A 2025 study examined topical carnosine gel during repeated high-intensity exercise in world-class rugby sevens players.
SPRINT 01/126 S MAXREC ●
007 / THE TEST
Topical carnosine gel improves intermittent high-intensity exercise performance in world-class rugby sevens players
Journal
Journal of the International Society of Sports Nutrition
Year
2025
Participants
7 world-class rugby sevens players
Design
Counterbalanced crossover • Triple-blind
Experience
1,452 international caps (combined)
PROTOCOL
0110 mLtopical gel
0240–45 MINapplied approximately 40–45 minutes before testing
0312intermittent cycling sprints
042 MINbreak after Sprint 6
05ALL 12sprints measured
Each work interval: 24 s cycling at 3 W/kg → 6 s maximal sprint → 30 s rest
WHAT THEY MEASURED
PEAK POWER
MEAN POWER
HEART RATE
PERCEIVED EXERTION
Not every outcome changed.
PEAK POWER WAS HIGHER IN SPECIFIC SPRINTS.
TOPICAL CARNOSINE GEL VS PLACEBO
SPRINT 21,433 Wvs 1,332 W placebo
SPRINT 41,347 Wvs 1,244 W placebo
SPRINT 71,426 Wvs 1,270 W placebo
01
02
03
04
05
06
07
08
09
10
11
12
Significant between-condition differences in peak power were reported in Sprints 2, 4 and 7.
NOT EVERYTHING CHANGED.
The study found no treatment effect for mean power output, heart rate or ratings of perceived exertion.
+5–10%
The researchers' plain-language summary described the observed acute performance effect as approximately +5–10%.
WHAT DID THE STUDY SHOW?
In this small group of world-class rugby sevens players, topical carnosine gel was associated with higher peak power during several of the repeated sprint efforts compared with placebo.
The findings are preliminary and should not be interpreted as evidence that every athlete, sport or exercise session will respond the same way.
WHAT REMAINS TO BE ANSWERED?
Whether the same effects occur in larger populations
Whether similar results occur in other sports
The precise mechanism responsible for the observed performance differences
Whether topical application increased intramuscular carnosine in these human participants
The researchers noted that future research should determine whether topical carnosine gels increase intramuscular carnosine concentrations in humans.
TWO STUDIES. TWO DIFFERENT QUESTIONS.
EQUINE
Question
Can topical carnosine increase measured carnosine inside skeletal muscle?
Finding
Higher intramuscular carnosine was measured at 30 and 60 minutes versus placebo.
HUMAN
Question
Could topical carnosine gel affect repeated high-intensity performance?
Finding
Higher peak power was observed in several specific sprint efforts versus placebo.
Together, they build an intriguing research story — but they do not answer every question.
HUMAN PRODUCT
MEET LACTIGO.
A topical carnosine gel developed for human performance use.
TOPICAL
CARNOSINE-BASED
PERFORMANCE-FOCUSED
SPRINT
TRAIN
COMPETE
MOVE
Running
Cycling
Team Sports
Gym / Strength
High-intensity training
Competitive athletes
Active adults
THE SCIENCE NOW SPANS MUSCLE DELIVERY AND HUMAN PERFORMANCE.
Always refer to the current product label for the most up-to-date ingredient information.
What about Fortigo?
Fortigo is the animal-use product in The Carnosine system. Its full formula should be presented separately once the current manufacturer ingredient information is verified.
Formula explains what's in the product. Evidence explains why the story matters.
Now let's hear from the people using it.
↓
Knowledge hub
Questions about carnosine?
Start with the questions people ask before they understand the science, the products, or the difference between human and animal use.
Human / LactiGo
LactiGo is a topical carnosine-based gel developed for human performance use. The regular product featured on The Carnosine is for external human use.
Yes. LactiGo is the human-use product in The Carnosine system. Fortigo is the animal-use product.
Apply enough gel to cover the target external area and massage it in until absorbed. For pre-activity use, current product directions recommend applying to clean, dry skin approximately 30–45 minutes before physical activity. Always follow the current product label.
The product is positioned for topical use around activity, including before or after activity. Always follow the current product directions for the specific LactiGo product you are using.
The regular LactiGo product currently featured on The Carnosine is the 100 mL size. Other LactiGo formats may also be available.
The regular 100 mL formula currently featured includes water, glycerin, carnosine, magnesium sulfate, ethoxydiglycol, phenoxyethanol, xanthan gum, caprylyl glycol and sorbic acid. Always check the current product label for the most up-to-date ingredient information.
Not every LactiGo formula is the same. The regular 100 mL formula featured in this section does not list menthol, while some LactiGo variants may contain additional ingredients such as menthol.
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Performance starts inside the muscle.
Choose the product built for your performance world.